World Library  

Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Genetics : Genome-wide Meta-analysis for Serum Calcium Identifies Significantly Associated Snps Near the Calcium-sensing Receptor Casr Gene, Volume 6

By Abecasis, Gonc¸alo R.

Click here to view

Book Id: WPLBN0003929702
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Genetics : Genome-wide Meta-analysis for Serum Calcium Identifies Significantly Associated Snps Near the Calcium-sensing Receptor Casr Gene, Volume 6  
Author: Abecasis, Gonc¸alo R.
Volume: Volume 6
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Historic
Publication Date:
Publisher: Plos

Description
Description : Calcium has a pivotal role in biological functions, and serum calcium levels have been associated with numerous disorders of bone and mineral metabolism, as well as with cardiovascular mortality. Here we report results from a genome-wide association study of serum calcium, integrating data from four independent cohorts including a total of 12,865 individuals of European and Indian Asian descent. Our meta-analysis shows that serum calcium is associated with SNPs in or near the calcium-sensing receptor (CASR) gene on 3q13. The top hit with a p-value of 6.3610-37 is rs1801725, a missense variant, explaining 1.26% of the variance in serum calcium. This SNP had the strongest association in individuals of European descent, while for individuals of Indian Asian descent the top hit was rs17251221 (p = 1.1610-21), a SNP in strong linkage disequilibrium with rs1801725. The strongest locus in CASR was shown to replicate in an independent Icelandic cohort of 4,126 individuals (p = 1.02610-4). This genome-wide meta-analysis shows that common CASR variants modulate serum calcium levels in the adult general population, which confirms previous results in some candidate gene studies of the CASR locus. This study highlights the key role of CASR in calcium regulation.

 
 


Copyright © World Library Foundation. All rights reserved. eBooks from World Journals, Database of Academic Research Journals are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.